OGC Speaker Series
Air date: 4/2/2015 12:15:00 PM
The purpose of this rehabilitation symposium is to disseminate the findings of a subject matter expert group comprised of clinical and research NIH Staff, and nationally recognized subject matter experts regarding cancer rehabilitation practice in the United States. The conference will present current practice models in cancer rehabilitation, identify evidence and practical considerations for the use of clinical, functional measurement tools and will discuss clinical integration of rehabilitation services into the oncology continuum of care and survivorship.
For more information go to http://www.cc.nih.gov/rmd/crc/index.html
Air date: 6/8/2015 8:00:00 AM
Workshop will review the landscape of past and future technologies for delivering nucleic acid (NA) antigens into target tissues of animal models and humans, with a focus on the prevention and treatment of human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS), among other priority diseases.
Air date: 5/21/2015 8:00:00 AM
Dr. Douglas Lowy is hosting a Town Hall Meeting with NCI staff.
Air date: 4/8/2015 11:00:00 AM
The National Advisory Council on Aging (NACA) advises the Secretary of the U.S. Department of Health and Human Services, the Director of NIH, and the Director of NIA on its mission. The Council meets three times a year to consider applications for research and training.
Air date: 5/13/2015 8:00:00 AM
DNA Repair Intererst Group videoconference
Air date: 5/12/2015 12:30:00 PM
For more information go to http://iprcc.nih.gov
Air date: 4/17/2015 8:00:00 AM
This is the third seminar in the FY2015 DDM Seminar Series. To receive credit for watching the LIVE Videocast, you need to register for the event in LMS on the morning of the event. Archived Videocast registration is also available in LMS approximately 10 days after the event.
Dr. Sian Beilock is Vice Provost for academic initiatives, a professor in the Department of Psychology, and a member of the Committee on Education at The University of Chicago. She is one of the world’s leading experts on the brain science behind “choking under pressure” and the many brain and body factors influencing all types of performance: from test-taking to public speaking to your golf swing. Beilock has authored two books – Choke and How the Body Knows Its Mind - and over 90 peer-reviewed publications in outlets such as Science and Journal of Neuroscience. Her research is funded by the U.S. Department of Education and the National Science Foundation (including a CAREER award). Beilock’s work is routinely covered in the media, ranging from CNN and NPR to The New York Times and Wall Street Journal. She was chosen as one of twenty-five “Women to Watch” by Crain’s Chicago Business Magazine in 2007 and received an award for Transformative Early Career Contributions from the Association for Psychological Science in 2011.
Join Dr. Beilock for an enlightening conversation on how to perform your best under stress. Explore what happens in the brain and body during stressful situations, whether one time-situational or chronic. Plan to learn about the psychological tools available to improve communication, thinking, and reasoning when the pressure is on.
For more information go to http://www.ddmseries.od.nih.gov
Air date: 4/9/2015 11:00:00 AM
Perturbations in post-translational modifications (PTMs) and their downstream effects are recognized as key drivers of disease. We have developed iPTMnet, employing an integrative bioinformatics approach—combining text mining, data mining, and ontological representation to capture rich PTM information—for PTM network and disease discovery. Text mining tools are used for full-scale mining of PubMed abstracts and PMC Open Access articles to identify PTM information (kinase, substrate, and site) and phosphorylation-dependent protein-protein interactions (PPIs) in their biological context, including disease consequences. Experimentally observed PTMs, including high-throughput proteomic data from curated PTM databases, are incorporated. Ontologies are used for knowledge representation, particularly the Protein Ontology (PRO) for representation of PTM proteoforms and complexes. The web portal (http://proteininformationresource.org/iPTMnet) supports online search and visual analysis, including multiple-sequence alignment views for comparison of PTM forms across organisms and Cytoscape visualization of PTM enzyme-substrate and PPI relationships in PTM interaction networks.
We are conducting use cases for PTM-disease discovery. First, we analyzed phosphorylation-dependent PPIs related to the PI3K/AKT/mTOR pathway, which is deregulated in many cancers and is targeted by therapeutic kinase inhibitors. We classified interactions as pro- and anti-oncogenic to indicate potential mechanisms of kinase-inhibitor resistance. Second, we made a knowledge map of beta-catenin PTM proteoforms to interpret patterns of mutations in PTM sites occurring in different types of cancer, revealing multiple mechanisms through which mutations in beta-catenin PTM sites contribute to cancer. Finally, we are exploring the phosphorylation of pyruvate dehydrogenase (PDHA1), a mediator of the Warburg effect in cancer whose phosphorylation levels span a 64-fold range in breast cancer patient samples from phosphoproteomic data CPTAC. We are investigating the levels and activity of PDHA1 kinases and phosphatases in the same samples using genomic, transcriptomic (mRNA and miRNA), and proteomic data to gain insight into the efficacy of existing anti-cancer drugs that target PDHA1 phosphorylation.
For more information go to http://proteome.nih.gov
Air date: 4/2/2015 10:00:00 AM