The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an Annual Immunology Retreat.
For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx
Air date: 3/4/2015 4:15:00 PM
BSSR Lecture Series
The NIH Office of Behavioral and Social Science Research presents the lecture Epigenetic mechanisms in memory formation by Dr. J. David Sweatt, University of Alabama at Birmingham.
Dr. Sweatt’s presentation is part of the 2014-2015 Behavioral and Social Sciences Research Lecture Series to promote open and engaged discussion about cutting edge research in the behavioral and social sciences field.
Regulation of chromatin structure and control of direct methylation of DNA are the principal mechanisms of epigenetic regulation. This presentation will address the idea that conservation of epigenetic mechanisms for information storage represents a unifying model in biology, with epigenetic mechanisms being utilized for cellular memory at levels from behavioral memory to development to cellular differentiation. Do epigenetic mechanisms operate in behavioral memory formation, including reward-based learning? We have generated several lines of evidence that support this idea that I will discuss.
1. Contextual fear conditioning and reward conditioning trigger alterations in hippocampal DNA methylation and histone post-translational modifications.
2. Inhibitors of DNA methylation block both hippocampal LTP and associative learning in vivo.
3. Remote contextual fear memory is associated with persisting changes in DNA methylation in the Anterior Cingulate Cortex, and DNMT inhibition can reverse established remote memory.
4. Histone acetylation increases in memory formation, and histone deacetylase (HDAC) inhibitors enhance both memory formation and hippocampal long-term potentiation.
5. Histone subunit exchange controls long-term and remote memory stabilization for threat learning.
For more information go to http://obssr.od.nih.gov
Air date: 3/13/2015 2:00:00 PM
Neuroscience Seminar Series
Air date: 4/6/2015 12:00:00 PM
Wednesday Afternoon Lecture Series
The Doudna lab pursues mechanistic understanding of fundamental biological processes involving RNA molecules. Research in the lab is currently focused on three major areas: bacterial immunity via the CRISPR system, RNA interference in eukaryotes, and translational control logic. We utilize diverse techniques including X-ray crystallography, high-throughput sequencing, biochemistry, molecular biology, and eukaryotic cell culture.
For more information go to http://wals.od.nih.gov
Air date: 3/11/2015 3:00:00 PM
To evaluate key issues involved in using chronic disease endpoints for setting dietary reference intakes and to describe the advantages and disadvantages of the identified options to suggest options for addressing them.
The upcoming workshop is anticipated to be the first step in a larger in-depth process for addressing the challenges involved in using chronic disease endpoints in the setting of DRI values. As warranted, subsequent activities will address additional issues that arise from the proposed workshop or that have been identified in earlier activities but were not covered in the currently proposed workshop. The final policy decisions as to how to revise the DRI process will need to be resolved by a future IOM-sponsored committee.
For more information go to http://ods.od.nih.gov
Air date: 3/11/2015 8:30:00 AM
The Office of AIDS Research will address maximizing U.S. agency partnerships for international HIV/AIDS research. Also an update will be provided o nthe lastest changes made to the federal treatment and prevention guidelines by the OARAC working groups responsible for the guidelines.
Air date: 4/16/2015 8:30:00 AM