CSR Director's Seminar
Dr. Jane Aubin, Chief Scientific Officer and Vice President of Research, and Ms. Jen O'Donoughe, Executive Director of Reforms Implementation at the Canadian Institutes of Health Research (CIHR) will provide an overview of how CIHR is reforming the grants and peer review processes to transform the way investigator initiated research is funded. This includes implementing two new funding schemes and making significant changes to peer review processes including the use of application focused review, structured peer review, remote review and new scoring processes. CIHR is mid-way through their implementation and will provide an overview of the results of the early pilot studies which are showing improved effectiveness as well as reductions in both applicant and reviewer burden. The presentation will also highlight lessons learned to date. You may submit questions for the speakers to firstname.lastname@example.org
Air date: 4/27/2015 10:00:00 AM
This is part of an ongoing series of lectures by experts in the field of global health and human services, hosted by Secretary Burwell. The Secretary will give brief remarks and then the speaker will give a 20-25 minute presentation, followed by Q&A. The event will be open and Videocast to HHS employees ONLY.
Air date: 3/10/2015 12:30:00 PM
Immunology Interest Group
Dr. David Masopust is the front-runner in our race to understand T cell memory formation and maintenance. His break-through studies on migration and effector function of memory CD8 T cells have re-shaped the field, and his current work on viral and bacterial vaccines that target tissue resident T cells has opened up new avenues in cellular immunology.
Dave’s fascination with T cell memory started with his PhD work in Leo Lefrancois’ lab at U. Conn, where he studied the migration and tissue distribution of memory cells. It was his pioneering work during that time that resulted in the landmark paper in Science, describing a new T cell subset that we now know as Tissue resident memory cells or TRM. Dave continued his interest in T cell memory during his post-doctoral training in Rafi Ahmed’s lab at Emory, where he studied memory formation upon viral infection and also got interested in the mechanisms that regulate the size and the repertoire of the memory T cell pool. These questions remained his major interests even after establishing his own lab at University of Minnesota, and he already provided us with new insights by demonstrating that the size of the memory CD8 T cell compartment is flexible and not static as previously proposed.
Dave’s research on T cell memory helped shaping new paradigms in immunology, such as the identification of tissue resident memory cells that provide immediate and local protection at the site of infection. The importance of his research is illustrated by his many awards, including the 2009 NIH Director’s New Innovator Award, The Beckman Foundation Young Investigator Award, and the American Society for Microbiology Young Investigator Award.
For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx
Air date: 3/11/2015 4:00:00 PM
Neuroscience Seminar Series
Air date: 4/27/2015 12:00:00 PM
To evaluate key issues involved in using chronic disease endpoints for setting dietary reference intakes and to describe the advantages and disadvantages of the identified options to suggest options for addressing them.
The upcoming workshop is anticipated to be the first step in a larger in-depth process for addressing the challenges involved in using chronic disease endpoints in the setting of DRI values. As warranted, subsequent activities will address additional issues that arise from the proposed workshop or that have been identified in earlier activities but were not covered in the currently proposed workshop. The final policy decisions as to how to revise the DRI process will need to be resolved by a future IOM-sponsored committee.
For more information go to http://ods.od.nih.gov
Air date: 3/11/2015 8:30:00 AM
The 56th meeting of the NCI Board of Scientific Advisors
Air date: 3/11/2015 8:30:00 AM
BSSR Lecture Series
The NIH Office of Behavioral and Social Science Research presents the lecture Epigenetic mechanisms in memory formation by Dr. J. David Sweatt, University of Alabama at Birmingham.
Dr. Sweatt’s presentation is part of the 2014-2015 Behavioral and Social Sciences Research Lecture Series to promote open and engaged discussion about cutting edge research in the behavioral and social sciences field.
Regulation of chromatin structure and control of direct methylation of DNA are the principal mechanisms of epigenetic regulation. This presentation will address the idea that conservation of epigenetic mechanisms for information storage represents a unifying model in biology, with epigenetic mechanisms being utilized for cellular memory at levels from behavioral memory to development to cellular differentiation. Do epigenetic mechanisms operate in behavioral memory formation, including reward-based learning? We have generated several lines of evidence that support this idea that I will discuss.
1. Contextual fear conditioning and reward conditioning trigger alterations in hippocampal DNA methylation and histone post-translational modifications.
2. Inhibitors of DNA methylation block both hippocampal LTP and associative learning in vivo.
3. Remote contextual fear memory is associated with persisting changes in DNA methylation in the Anterior Cingulate Cortex, and DNMT inhibition can reverse established remote memory.
4. Histone acetylation increases in memory formation, and histone deacetylase (HDAC) inhibitors enhance both memory formation and hippocampal long-term potentiation.
5. Histone subunit exchange controls long-term and remote memory stabilization for threat learning.
For more information go to http://obssr.od.nih.gov
Air date: 3/13/2015 2:00:00 PM
Neuroscience Seminar Series
Air date: 4/6/2015 12:00:00 PM