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5/29/2015
NIH Director's Seminar Series

The discovery that expression of lysosomal genes is not constitutive but changes in response to nutrient status revealed that cells monitor lysosomal function and respond to degradation requirements and environmental conditions. The transcription factors TFEB and TFE3 rapidly translocate from the cytosol to the nucleus following starvation. By regulating expression of numerous genes implicated in lysosomal biogenesis, autophagy, and metabolism, TFEB and TFE3 play a critical role in maintaining cellular homeostasis and energy metabolism.

Our recent work reveals that TFEB and TFE3 may have a broader role than previously recognized in cellular response to stress by regulating host immune response to pathogen infection. In addition, the ability of TFEB and TFE3 to induce lysosomal exocytosis and cellular clearance makes them promising therapeutic target for the treatment of lysosomal and neurological disorders.

Air date: 6/5/2015 12:00:00 PM


5/29/2015

The fourth installment of the FY2015 DDM Seminar Series. To receive credit for watching the LIVE Videocast, you need to register for the event in LMS on the morning of the event. Archived Videocast registration is also available in LMS approximately 10 days after the event.

Fascinated by the leaders and companies that make the greatest impact in the world, those with the capacity to inspire, trained ethnographer Simon Sinek has discovered some remarkable patterns of how they think, act and communicate. He has devoted his life to sharing his thinking in order to help other leaders and organizations inspire action. This is an opportunity to hear what we can do to “create cultures that inspire people to give all they have to give simply because they love where they work” (from" Leaders Eat Last").

For more information go to http://www.ddmseries.od.nih.gov/

Air date: 6/4/2015 10:00:00 AM


5/29/2015

Wednesday Afternoon Lecture Series (WALS)

For more information go to https://oir.nih.gov/wals

Air date: 6/24/2015 3:00:00 PM


5/29/2015

5th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board

Air date: 6/24/2015 9:00:00 AM


5/29/2015

RAC Meeting Special Workshop

The NIH Recombinant DNA Advisory Committee (RAC) will review and discuss selected human gene transfer protocols and related data management activities. For more information, please check the meeting agenda at OBA Meetings Page (available at the following URL:
http://osp.od.nih.gov/office-biotechnology-activities/event/2015-06-09-160000-2015-06-10-210000/rac-meeting


Air date: 6/10/2015 8:30:00 AM


5/29/2015

Neuroscience Seminar Series

Dr. Mayberg received a BA in psychobiology from University of California, Los Angeles and an MD from University of Southern California. She is a Board Certified Neurologist, trained at the Neurological Institute of NY at Columbia University and a post-doctoral fellowship in Nuclear Medicine at the Johns Hopkins Medical Institutions.

Dr Mayberg heads a multidisciplinary depression research program dedicated to the study of brain circuits in depression and the effects of various antidepressant treatments measured using a variety of functional and structural imaging tools. The primary focus of the lab to development imaging and physiological based algorithms that will discriminate depressed patient subgroups and optimize treatment selection at all stages of the illness. Imaging findings provided the foundation for development and testing of deep brain stimulation (DBS) of the subcallosal cingulate region (Area 25), a novel intervention for patients with treatment resistant depression.

She was recently named as one of Emory University’s “Game Changers” in recognition of her pioneering DBS research which has been heralded as a one of the first hypothesis-driven treatment strategies for a major mental illness. Clinical trials are now ongoing in both North America and Europe. At Emory, DBS studies aim to refine, optimize and extend the potential of this treatment strategy with experiments designed to characterize and define mechanisms mediating DBS response and to develop biomarkers that will improve patient selection, enhance precision of surgical targeting and optimize stimulation parameters.

Air date: 6/1/2015 12:00:00 PM


5/29/2015

Advisory Board Meeting

Air date: 6/9/2015 12:00:00 PM


5/29/2015

The purpose of the workshop is to identify obstacles to RSV vaccine development, discuss approaches to alleviating them, and identify gaps in research that could be addressed to enable vaccine development. The meeting will also review the basic science and clinical data that will inform the regulation of products under development including, for example, immune responses to RSV primary infection and reinfection, and the physiology and kinetics of placental antibody transfer as well as discuss progress towards standardization of immunologic agents and assays. Lessons learned from previous clinical trials of RSV vaccines, and polyclonal and monoclonal antibodies used for immune-prophylaxis will be discussed to identify potential serological and clinical endpoints for upcoming pivotal trials.

Air date: 6/1/2015 8:30:00 AM


5/29/2015

The purpose of the workshop is to identify obstacles to RSV vaccine development, discuss approaches to alleviating them, and identify gaps in research that could be addressed to enable vaccine development. The meeting will also review the basic science and clinical data that will inform the regulation of products under development including, for example, immune responses to RSV primary infection and reinfection, and the physiology and kinetics of placental antibody transfer as well as discuss progress towards standardization of immunologic agents and assays. Lessons learned from previous clinical trials of RSV vaccines, and polyclonal and monoclonal antibodies used for immune-prophylaxis will be discussed to identify potential serological and clinical endpoints for upcoming pivotal trials.

Air date: 6/2/2015 8:30:00 AM


5/28/2015

The National Institute of Dental and Craniofacial Research (NIDCR) and the Fogarty International Center present the 2015 David E. Barmes Global Health Lecture:"Medical Research and Capacity Building for Development: The Experience of Rwanda," delivered by Rwandan Health Minister, Dr. Agnes Binagwaho. The lecture will take place on Wednesday, July 29, at 11:30 a.m. in Masur Auditorium, Clinical Center (Building 10).

Dr. Agnes Binagwaho, Minister of Health of the Republic of Rwanda, has spoken frequently about the value of research and capacity building at her country’s medical and academic institutions in helping relieve the disease burden that weighs on Rwandan and other LMIC populations.

Before becoming minister in 2011, she had served as permanent secretary of health, as executive secretary of Rwanda’s National AIDS Control Commission and as a physician in public hospitals for over 15 years. She trained in pediatrics, specialized in emergency neonatology and the treatment of HIV/AIDS, and earned her doctoral degree from the University of Rwanda in 2014. She holds positions at Harvard University and Dartmouth College, where she teaches courses in health equity, HIV/AIDS, information and communication technologies for health, and pediatric care delivery systems.

NIH supports a range of research and training collaborations with Rwandan scientists, such as clinical trials of an HIV vaccine, development of research skills to study cervical and other cancers, and investigations of how intimate partner violence affects health.

The David E. Barmes Global Health Lecture series honors the late David Edward Barmes, special expert for international health in the National Institute of Dental and Craniofacial Research (NIDCR).

Prior to joining NIDCR, Dr. Barmes, a public health dentist and epidemiologist by training, served in senior management positions related to oral health, health promotion, and non-communicable diseases at the World Health Organization in Geneva. The lecture series was established by the NIDCR and Fogarty in 2001 to honor his lifelong dedication to research aimed at improving health for those in low-income countries.

For more information go to http://www.fic.nih.gov/News/Events/Pages/Barmes-Lecture.aspx

Air date: 7/29/2015 11:30:00 AM


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This page last reviewed: December 14, 2010